DMcloud is a macromolecular modeling tool for local structure fitting using point cloud matching with a diffusion model for cryo-EM maps at < 10Å resolution

It is especially useful when fitting models, such as those from AlphaFold, that may be globally incorrect but contain accurate local structures.

If encounter problems, please contact Daisuke Kihara (dkihara@purdue.edu) or Xiao Wang (xiaowang20140001@gmail.com) or Genki Terashi (gterashi@purdue.edu)

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Example EMD-1461
Input Map file: emd_1461.mrc

Input AF2 template file: emd_2513_af2.pdb

Contour level: 0.05

Result Example:Result Example with full-atom model building

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Please simply click "Upload" when you filled all input fields.

Please do not input 0, you must provide a contour to remove the outside very noisy regions

contour_level :


resolution :


cryo_em_map :


fasta(protein) :


fasta(DNA) :


fasta(RNA) :